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Extent of Myocardial Ischemia on Positron Emission Tomography and Survival Benefit with Early Revascularization

A recent clinical study performed in 322 patients  was the first randomized comparison of  the clinical effectiveness of pharmacologic stress PET with rubidium-82 or SPECT with technetium-99m in symptomatic patients undergoing risk stratification for coronary artery disease.

It was found that a higher proportion of patients with high-risk findings on PET imaging underwent coronary revascularization on follow-up than those undergoing SPECT and that a lower proportion of patients with low-risk findings on PET underwent follow-up catheterization than on SPECT. This suggests that PET supports better risk assessment than SPECT resulting in improved downstream use.

Patel KK et al., Extent of Myocardial Ischemia on Positron Emission Tomography and Survival Benefit with Early Revascularization, J Am Coll Cardiol. 2019 Oct 1; 74(13): 1645–1654.

Article: Extent of Myocardial Ischemia on Positron Emission Tomography and Survival Benefit with Early Revascularization